TEDMED 2011
Bill Doyle: Treating cancer with electric fields
Bill Doyle: Liječenje raka električnim poljima
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Operacija, kemoterapija i zračenje najpoznatije su metode liječenja raka. Na TEDMED-u Bill Doyle predstavlja novi pristup pod nazivom Polja za liječenje tumora koji koristi električna polja kako bi prekinuo dijeljenje stanica raka. Iako je još u začecima -- i dokazan samo za određene vrste raka -- liječenje dolazi s velikom koristi: kvalitetom života.
Bill Doyle - Engineer
With his company Novocure, Bill Doyle works to bring breakthrough medical technologies to doctors and patients. Full bio
With his company Novocure, Bill Doyle works to bring breakthrough medical technologies to doctors and patients. Full bio
Double-click the English transcript below to play the video.
00:15
Everybody in our society's life is touched by cancer --
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Svi iz našeg društvenog života na neki su način povezani s rakom --
00:18
if not personally,
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ako ne osobno,
00:20
then through a loved one, a family member,
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onda preko voljene osobe, člana obitelji,
00:23
colleague, friend.
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kolege, prijatelja.
00:25
And once our lives are touched by cancer,
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I jednom kada su naši životi dotaknuti rakom
00:28
we quickly learn
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brzo naučimo
00:30
that there are basically
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da u principu imamo
00:32
three weapons, or three tools, that are available
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tri oružja ili tri alata koji su dostupni
00:35
to fight the disease:
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u borbi s bolešću:
00:38
surgery, radiation and chemotherapy.
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operacija, zračenje i kemoterapija.
00:41
And once we get involved
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I jednom kad se uključimo
00:44
in the therapeutic decisions,
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u terapeutske odluke,
00:47
again either personally
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opet nebitno je li osobno
00:49
or with our loved ones and family members,
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ili s našim voljenima i članovima obitelji,
00:52
we also very quickly learn
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također brzo naučimo
00:55
the benefits, the trade-offs and the limitations
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prednosti, pogodnosti i ograničenja
00:58
of these tools.
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tih alata.
01:00
I'm very thankful to Jay and to Mark
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Veoma sam zahvalan Jayu i Marku
01:02
and the TEDMED team
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i TEDMED ekipi
01:04
for inviting me today
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što su me danas pozvali
01:06
to describe a fourth tool, a new tool,
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kako bih opisao četvrti alat
01:09
that we call Tumor Treating Fields.
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koji nazivamo Poljima za liječenje tumora.
01:12
Tumor Treating Fields
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Polja za liječenje tumora
01:14
were invented by Dr. Yoram Palti,
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pronašao je dr. Yoram Palti,
01:17
professor emeritus at the Technion in Israel.
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umirovljeni profesor na Technionu u Izraelu.
01:20
And they use low-intensity
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Oni koriste električna polja
01:22
electric fields
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niskog intenziteta
01:24
to fight cancer.
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kako bi se borili protiv raka.
01:26
To understand how Tumor Treating Fields work,
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Da bismo razumjeli kako Polja za liječenje raka djeluju,
01:29
we first need to understand
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prvo moramo razumjeti
01:31
what are electric fields.
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što su to električna polja.
01:33
Let me first address
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Prvo ću vam reći
01:36
a few popular misconceptions.
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nekoliko poznatih pogrešnih tumačenja.
01:39
First of all, electric fields
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Prije svega, električna polja
01:41
are not an electric current
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nisu električna struja
01:43
that is coursing through the tissue.
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koja teče kroz tkivo.
01:46
Electric fields
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Električna polja
01:48
are not ionizing radiation,
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nisu ionizirajuće zračenje
01:50
like X-rays or proton beams,
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poput rentgenskih zraka ili snopova protona
01:52
that bombard tissue
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koji bombardiraju tkivo
01:54
to disrupt DNA.
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kako bi prekinuli DNK.
01:56
And electric fields
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Električna polja
01:58
are not magnetism.
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nisu magnetizam.
02:00
What electric fields are
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Ono što električna polja jesu
02:02
are a field of forces.
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su polja snage.
02:05
And these forces
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A te snage
02:07
act on, attract, bodies
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djeluju na tj. privlače tijela
02:10
that have an electrical charge.
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koja imaju električni naboj.
02:13
The best way to visualize an electric field
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Najbolji način da zamislite električno polje
02:15
is to think of gravity.
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je da zamislite gravitaciju.
02:17
Gravity is also a field of forces
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Gravitacija je također polje snage
02:20
that act on masses.
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koje djeluje na masu.
02:22
We can all picture astronauts in space.
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Svi možemo zamisliti astronaute u svemiru.
02:25
They float freely in three dimensions
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Oni slobodno lebde u tri dimenzije
02:27
without any forces acting on them.
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bez da ikakve sile djeluju na njih.
02:29
But as that space shuttle
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Ali kada se taj svemirski brod
02:32
returns to Earth,
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vrati na Zemlju
02:34
and as the astronauts enter the Earth's gravitational field,
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i astronauti uđu u Zemljino gravitacijsko polje,
02:37
they begin to see the effects of gravity.
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počinju uviđati efekte gravitacije.
02:40
They begin to be attracted towards Earth.
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Privučeni su ka Zemlji.
02:42
And as they land,
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I kada slete,
02:44
they're fully aligned in the gravitational field.
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potpuno su postrojeni u gravitacijskom polju.
02:46
We're, of course, all stuck in the Earth's gravitational field right now.
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Mi smo svi, naravno zapeli trenutno u Zemljinom gravitacijskom polju.
02:49
That's why you're all in your chairs.
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Zbog toga ste svi u stolicama.
02:52
And that's why we have to use our muscle energy
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I zbog toga moramo upotrijebiti mišićnu energiju
02:54
to stand up, to walk around
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da bismo ustali, hodali
02:56
and to lift things.
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i podizali stvari.
02:59
In cancer,
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Kod raka,
03:01
cells rapidly divide
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stanice se brzo dijele
03:03
and lead to uncontrolled tumor growth.
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i dovode do nekontroliranog rasta tumora.
03:06
We can think of a cell
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Možemo razmišljati o stanici
03:09
from an electrical perspective
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iz električne perspektive
03:11
as if it's a mini space station.
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kao da je malena svemirska stanica.
03:14
And in that space station
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I u toj svemirskoj stanici
03:16
we have the genetic material, the chromosomes,
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imamo genetski materijal, kromosome
03:19
within a nucleus.
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unutar jezge.
03:21
And out in the cytoplasmic soup
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A vani, u citoplazmatskoj juhi
03:23
we have special proteins
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imamo posebne proteine
03:25
that are required for cell division
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koji su potrebni za dijeljenje stanica
03:27
that float freely in this soup
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koji slobodno lebde u toj juhi
03:29
in three dimensions.
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u tri dimenzije.
03:31
Importantly, those special proteins
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Važno je napomenuti da su ti posebni proteini
03:34
are among the most highly charged objects
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među najjače nabijenim stvarima
03:37
in our body.
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u našem tijelu.
03:39
As cell division begins
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Kada dijeljenje stanica počne,
03:41
the nucleus disintegrates,
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jezgra se raspada,
03:43
the chromosomes line up
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kromosomi se poredaju
03:45
in the middle of the cell
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u sredini stanice
03:47
and those special proteins
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i ti posebni proteini
03:49
undergo a three-dimensional sequence
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dožive trodimenzionalni niz
03:53
whereby they attach
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gdje se pričvrste
03:55
and they literally click into place end-on-end
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i doslovno se spajaju na krajevima
03:58
to form chains.
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kako bi stvorili lance.
04:00
These chains
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Ti lanci
04:02
then progress and attach
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onda napreduju i pričvrste se
04:04
to the genetic material
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za genetski materijal
04:07
and pull the genetic material
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i povuku genetski materijal
04:09
from one cell into two cells.
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iz jedne stanice u dvije stanice.
04:11
And this is exactly how
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I upravo se na ovaj način
04:13
one cancer cell becomes two cancer cells,
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jedna stanica raka pretvara u dvije stanice raka,
04:15
two cancer cells become four cancer cells,
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dvije stanice raka postaju četiri stanice raka
04:17
and we have ultimately
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i u konačnici imamo
04:19
uncontrolled tumor growth.
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nekontrolirani rast tumora.
04:22
Tumor Treating Fields
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Polja za liječenje tumora
04:25
use externally placed transducers
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koriste izvana smještene pretvarače
04:29
attached to a field generator
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pričvršćene na generatoru polja
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to create an artificial electric field
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kako bi stvorili umjetno električno polje
04:36
on that space station.
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u toj svemirskoj stanici.
04:39
And when that cellular space station
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I kada je ta stanična svemirska stanica
04:42
is within the electric field,
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unutar električnog polja,
04:44
it acts on those highly charged proteins
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djeluje na te jako nabijene proteine
04:48
and aligns them.
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i postrojava ih.
04:50
And it prevents them from forming those chains,
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I sprječava ih od stvaranja tih lanaca,
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those mitotic spindles,
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tih mitotskih vretena
04:55
that are necessary to pull the genetic material
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koja su neophodna kako bi povukla genetski materijal
04:58
into the daughter cells.
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u stanicu kćeri.
05:00
What we see is that the cells will attempt to divide
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Ono što vidimo je da će se te stanice pokušati dijeliti
05:03
for several hours.
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nekoliko sati.
05:05
And they will either enter into
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I one će ili ući u
05:08
this so-called cellular suicide,
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to takozvano stanično samoubojstvo,
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programmed cell death,
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programiranu staničnu smrt
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or they will form unhealthy daughter cells
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ili će stvoriti nezdrave stanice kćeri
05:15
and enter into apoptosis
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i ući u apoptozu
05:18
once they have divided.
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jednom kada se podijele.
05:20
And we can observe this.
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I mi to možemo promatrati.
05:22
What I'm going to show you next
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Ono što ću vam sljedeće pokazati
05:24
are two in vitro experiments.
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su dva in vitro pokusa.
05:26
This is cultures, identical cultures,
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Ovo su kulture, identične kulture
05:29
of cervical cancer cells.
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stanica raka grlića maternice.
05:31
And we've stained these cultures
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Obojali smo te kulture
05:33
with a green florescent dye
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fluorescentno zelenom bojom
05:35
so that we can look at these proteins
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kako bismo mogli gledati proteine
05:38
that form these chains.
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koji formiraju lance.
05:40
The first clip shows
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Prvi isječak vam pokazuje
05:42
a normal cell division
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normalnu podjelu stanice
05:45
without the Tumor Treating Fields.
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bez Polja za liječenje tumora.
05:48
What we see
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Ono što vidimo
05:50
are, first of all, a very active culture,
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su, prije svega, veoma aktivne kulture,
05:52
a lot of divisions,
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mnogo podjela
05:54
and then very clear nuclei
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i veoma jasno vidljivu jezgru
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once the cells have separated.
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nakon što su se stanice podijelile.
05:58
And we can see them dividing throughout.
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I možemo ih vidjeti kako se sasvim dijele.
06:00
When we apply the fields --
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Kada primijenimo polja --
06:02
again, in the identical time-scale
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opet, u isto vrijeme --
06:04
to the identical culture --
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na identičnoj kulturi --
06:06
you're going to see something different.
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vidjet ćete nešto drugačije.
06:08
The cells round up for division,
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Stanice se okupe kako bi se dijelile,
06:10
but they're very static in that position.
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ali su veoma statične u toj poziciji.
06:13
We'll see two cells
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Vidjet ćemo dvije stanice
06:15
in the upper part of the screen
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u gornjem dijelu ekrana
06:20
attempting to divide.
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kako se pokušavaju podijeliti.
06:22
The one within the circle manages.
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Ova unutar kruga to i uspijeva.
06:24
But see how much of the protein
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Ali vidite koliko je proteina
06:26
is still throughout the nucleus,
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još uvijek unutar jezgre,
06:28
even in the dividing cell.
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čak i u stanici koja se dijeli.
06:30
The one up there can't divide at all.
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Ona tamo gore se uopće ne može podijeliti.
06:32
And then this bubbling, this membrane bubbling,
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A ovo stvaranje mjehurića, stvaranje mjehurića na membrani
06:35
is the hallmark
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je oznaka
06:37
of apoptosis in this cell.
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apoptoze u ovoj stanici.
06:40
Formation of healthy mitotic spindles
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Stvaranje zdravog mitotskog vretena
06:44
is necessary for division
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nužno je za dijeljenje
06:47
in all cell types.
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svih tipova stanica.
06:49
We've applied Tumor Treating Fields
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Primijenili smo Polja za liječenje tumora
06:51
to over 20 different cancers in the lab,
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na više od 20 različitih rakova u laboratoriju
06:54
and we see this effect
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i vidimo ovakav ishod
06:56
in all of them.
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na svima njima.
06:59
Now importantly,
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Važno je spomenuti
07:01
these Tumor Treating Fields have no effect
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da ova Polja za liječenje tumora nemaju učinka
07:04
on normal undividing cells.
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na normalne nedjeljive stanice.
07:06
10 years ago,
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Prije 10 godina
07:08
Dr. Palti founded a company called Novocure
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dr. Palti osnovao je tvrtku pod imenom Novocure
07:11
to develop his discovery
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kako bi razvio svoje otkriće
07:14
into a practical therapy for patients.
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u praktičnu terapiju za pacijente.
07:17
In that time, Novocure's developed two systems --
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U to vrijeme Novocure je razvio dva sistema --
07:21
one system for cancers in the head
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jedan sistem za rakove u glavi
07:24
and another system for cancers in the trunk of the body.
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i drugi sistem za rakove u trupu tijela.
07:27
The first cancer that we have focused on
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Prvi rak na koji smo se fokusirali
07:30
is the deadly brain cancer, GBM.
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smrtonosni je rak mozga, GBM (Glioblastoma Multiforme).
07:33
GBM affects about 10,000 people
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GBM pogađa oko 10.000 ljudi
07:36
in the U.S. each year.
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u SAD-u svake godine.
07:39
It's a death sentence.
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To je smrtna presuda.
07:41
The expected five year survival
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Očekivano preživljavanje u sljedećih pet godina
07:43
is less than five percent.
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je manje od 5%.
07:45
And the typical patient
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A tipičan pacijent
07:47
with optimal therapy
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s optimalnom terapijom
07:49
survives just a little over a year,
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poživi malo više od godine dana
07:52
and only about seven months
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i oko samo sedam mjeseci
07:54
from the time that the cancer is first treated
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od trenutka kada je rak prvi puta liječen,
07:57
and then comes back and starts growing again.
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a onda se vraća i počinje ponovo rasti.
08:02
Novocure conducted
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Novocure je proveo
08:04
its first phase three randomized trial
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svoju prvu fazu nasumičnih ispitivanja
08:06
in patients with recurrent GBM.
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na pacijentima s recidiviranim GBM-om.
08:08
So these are patients
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To su dakle pacijenti
08:10
who had received surgery,
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koji su operirani,
08:14
high dose radiation to the head
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glava im je ozračena visokim dozama
08:16
and first-line chemotherapy,
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i obavili su prvi niz kemoterapija
08:18
and that had failed and their tumors had grown back.
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i to nije uspjelo, pa su im se tumori ponovo vratili.
08:21
We divided the patients into two groups.
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Podijelili smo pacijente u dvije grupe.
08:24
The first group received second-line chemotherapy,
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Prva grupa primila je drugi niz kemoterapija
08:27
which is expected to double the life expectancy,
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za što je očekivano da će im udvostručiti životni vijek
08:30
versus no treatment at all.
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u odnosu na to da uopće nema liječenja.
08:32
And then the second group
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A druga je grupa
08:34
received only Tumor Treating Field therapy.
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primila samo terapiju Poljima za liječenje tumora.
08:37
What we saw in that trial
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Ono što smo u tom ispitivanju vidjeli
08:39
is that that the life expectancies of both groups --
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je to da je očekivan životni vijek u obje grupe --
08:42
so the chemotherapy treated group
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dakle, i onoj liječenoj kemoterapijom
08:44
and the Tumor Treating Field group --
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i onoj liječenoj Poljima za liječenje tumora --
08:46
was the same.
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bio jednak.
08:48
But importantly,
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Ali ono najvažnije,
08:50
the Tumor Treating Field group
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grupa liječena Poljima za liječenje tumora
08:53
suffered none of the side effects
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nije patila od nikakvih nuspojava
08:56
typical of chemotherapy patients.
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tipičnih za pacijente na kemoterapiji.
08:59
They had no pain,
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Nisu imali bolove
09:01
suffered none of the infections.
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niti su imali ikakve infekcije.
09:04
They had no nausea, diarrhea,
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Nisu imali vrtoglavice, proljev,
09:07
constipation, fatigue
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zatvor ni umor,
09:10
that would be expected.
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što je očekivano.
09:12
Based on this trial,
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Na temelju ovog ispitivanja,
09:14
in April of this year,
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u travnju ove godine
09:16
the FDA approved Tumor Treating Fields
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FDA je odobrila Polja za liječenje tumora
09:19
for the treatment of patients
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kao liječenje pacijenata
09:21
with recurrent GBM.
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s recidiviranim GBM-om.
09:24
Importantly, it was the first time ever
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Važno je napomenuti da je to prvi puta ikad
09:27
that the FDA included
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da je FDA u svoje
09:29
in their approval of an oncology treatment
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odobrenje za onkološko liječenje
09:32
a quality of life claim.
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uključila zahtijev za kvalitetom života.
09:36
So I'm going to show you now
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Pokazat ću vam sada
09:39
one of the patients
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jednog pacijenta
09:41
from this trial.
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iz ovog ispitivanja.
09:44
Robert Dill-Bundi
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Robert Dill-Bundi
09:46
is a famous Swiss cycling champion.
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poznati je švicarski biciklistički prvak.
09:48
He won the gold medal in Moscow
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Osvojio je zlatnu medalju u Moskvi
09:50
in the 4,000 meter pursuit.
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na takmičenju na 4.000 metara.
09:53
And five years ago,
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I prije 5 godina
09:56
Robert was diagnosed with GBM.
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Robertu je dijagnosticiran GBM.
09:59
He received the standard treatments.
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Primio je uobičajenu terapiju.
10:01
He received surgery.
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Operiran je.
10:04
He received high dose radiation to the head.
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Glava mu je zračena velikom dozom zračenja.
10:07
And he received first-line chemotherapy.
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I primio je prvi niz kemoterapija.
10:10
A year after this treatment --
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Godinu dana nakon tog liječenja --
10:12
in fact, this is his baseline MRI.
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zapravo, ovo je njegova osnovna MR slika.
10:15
You can see that the black regions
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Možete vidjeti da su crne regije
10:18
in the upper right quadrant
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u gornjem desnom kvadrantu
10:20
are the areas where he had surgery.
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područja gdje je obavljena operacija.
10:22
And a year after that treatment,
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I godinu dana nakon tog liječenja
10:24
his tumor grew back with a vengeance.
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njegov tumor je ponovo narastao s osvetom.
10:27
That cloudy white mass that you see
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Ta zamagljena bijela tvorba koju vidite
10:30
is the recurrence of the tumor.
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jest vraćanje tumora.
10:33
At this point, he was told by his doctors
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U tom trenu, doktori su mu rekli
10:36
that he had about 3 months to live.
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da ima još 3 mjeseca života.
10:39
He entered our trial.
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Prijavio se na naše ispitivanje.
10:41
And here we can see him getting the therapy.
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I ovdje vidimo kako prima terapiju.
10:44
First of all, these electrodes are noninvasive.
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Prije svega, ove elektrode su neinvazivne.
10:47
They're attached to the skin
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Pričvršćene su na kožu
10:49
in the area of the tumor.
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u području tumora.
10:51
Here you can see
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Ovdje vidite
10:53
that a technician is placing them on there much like bandages.
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kako ih tehničar stavlja tamo poput zavoja.
10:56
The patients learn to do this themselves
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Pacijenti to nauče sami raditi
10:59
And then the patients
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i onda pacijenti
11:02
can undergo all the activities of their daily life.
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mogu nastaviti sa svim aktivnostima svoje svakodnevice.
11:05
There's none of the tiredness.
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Nema umora.
11:07
There's none of what is called the "chemo head."
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Nema onoga što inače nazivaju „kemo glavom“.
11:10
There's no sensation.
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Nema osjećaja.
11:12
It doesn't interfere
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Ne interferira
11:14
with computers or electrical equipment.
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s računalima ili električnom opremom.
11:17
And the therapy is delivered continuously
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I terapija se može kontinuirano obavljati
11:19
at home,
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kod kuće
11:21
without having to go into the hospital
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bez da morate ići u bolnicu
11:23
either periodically or continually.
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s vremena na vrijeme ili stalno.
11:26
These are Robert's MRIs,
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Ovo su ponovo Robertove MR snimke,
11:29
again, under only TTField treatment.
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samo pod terapijom Polja za liječenje tumora.
11:32
This is a therapy that takes time to work.
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Ovo je terapija kojoj treba vremena da bi uspjela.
11:35
It's a medical device;
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To je medicinski uređaj;
11:37
it works when it's on.
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radi kad je uključen.
11:39
But what we can see is, by month six,
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Ali ono što možemo vidjeti, do šestog mjeseca,
11:41
the tumor has responded
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da je tumor reagirao
11:44
and it's begun to melt away.
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i počeo se otapati.
11:47
It's still there.
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Još uvijek je tamo.
11:49
By month 12,
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Do dvanaestog mjeseca
11:51
we could argue whether
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možemo raspravljati o tome
11:53
there's a little bit of material around the edges,
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ima li malo materijala na rubovima,
11:55
but it's essentially completely gone.
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ali je u suštini potpuno nestao.
11:58
It's now five years
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Sada je prošlo 5 godina
12:00
since Robert's diagnosis,
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od Robertove dijagnoze
12:02
and he's alive,
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i živ je,
12:05
but importantly, he's healthy
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ali važno je spomenuti da je zdrav
12:07
and he's at work.
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i da radi.
12:09
I'm going to let him, in this very short clip,
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Pustit ću ga da vam u ovom veoma kratkom isječku
12:11
describe his impressions of the therapy
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opiše utiske terapije
12:13
in his own words.
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vlastitim riječima.
12:15
(Video) Robert Dill-Bundi: My quality of life,
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(Video) Robert Dill-Bundi: Moja kvaliteta života,
12:17
I rate what I have today
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ocijenjujem ono što imam danas
12:19
a bit different than what most people would assume.
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malo drugačije no što bi većina ljudi pretpostavila.
12:23
I am the happiest, the happiest person in the world.
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Ja sam najsretnija, najsretnija osoba na svijetu.
12:28
And every single morning I appreciate life.
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I svakog jutra cijenim život.
12:32
Every night I fall asleep very well,
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Svake noći dobro zaspim
12:35
and I am, I repeat,
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i ja sam, ponavljam,
12:38
the happiest man in the world,
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najsretniji čovjek na svijetu
12:40
and I'm thankful I am alive.
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i zahvalan sam što sam živ.
12:45
BD: Novocure's also working on lung cancer
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BD: Novocure također radi na raku pluća
12:48
as the second target.
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kao drugom cilju.
12:50
We've run a phase two trial
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U drugoj smo fazi ispitivanja
12:52
in Switzerland
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u Švicarskoj,
12:54
on, again, recurrent patients --
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opet na pacijentima kojima se rak vratio --
12:56
patients who have received standard therapy
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pacijentima koji su dobili standardnu terapiju
12:59
and whose cancer has come back.
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i čiji se rak vratio.
13:02
I'm going to show you another clip
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Pokazat ću vam još jedan isječak
13:04
of a woman named Lydia.
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o ženi po imenu Lydia.
13:06
Lydia's a 66 year-old farmer
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Lydia je 66-ogodišnja farmerica
13:08
in Switzerland.
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u Švicarskoj.
13:10
She was diagnosed with lung cancer
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Rak pluća joj je dijagnosticiran
13:12
five years ago.
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prije pet godina.
13:14
She underwent four different regimes of chemotherapy
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Prošla je četiri različita režima kemoterapija
13:17
over two years,
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tijekom dvije godine
13:19
none of which had an effect.
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i nijedan nije imao učinka.
13:21
Her cancer continued to grow.
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Njen rak nastavio je rasti.
13:23
Three years ago,
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Prije tri godine
13:25
she entered the Novocure lung cancer trial.
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priključila se Novocureovom ispitivanju raka pluća.
13:29
You can see, in her case,
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U njenom slučaju možete vidjeti
13:31
she's wearing her transducer arrays,
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da nosi svoje nizove pretvarača,
13:33
one of the front of her chest, one on the back,
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jedan s prednje strane na prsima, jedan straga
13:36
and then the second pair side-to-side over the liver.
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i onda drugi par sa svake strane jetre.
13:39
You can see the Tumor Treating Field field generator,
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Možete vidjeti generator polja u Poljima za liječenje tumora,
13:42
but importantly you can also see that she is living her life.
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ali važno je da također možete vidjeti da ona živi svoj život.
13:45
She is managing her farm.
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Upravlja svojom farmom.
13:47
She's interacting with her kids and her grand kids.
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Komunicira sa svojom djecom i unučadi.
13:50
And when we talked to her,
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A kada smo razgovarali s njom
13:53
she said that when she was undergoing chemotherapy,
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rekla je da kada je bila pod kemoterapijom,
13:55
she had to go to the hospital every month for her infusions.
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morala je svaki mjesec ići u bolnicu kako bi primila infuziju.
13:58
Her whole family suffered
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Cijela obitelj joj je patila
14:00
as her side effect profile came and went.
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dok su joj nuspojave dolazile i prolazile.
14:02
Now she can run
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Sada može obavljati
14:04
all of the activities of her farm.
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sve aktivnosti na svojoj farmi.
14:07
It's only the beginning.
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To je samo početak.
14:09
(Applause)
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(Pljesak)
14:16
In the lab, we've observed tremendous synergies
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U laboratoriju smo promatrali ogromne sinergije
14:20
between chemotherapy and Tumor Treating Fields.
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između kemoterapije i Polja za liječenje raka.
14:23
There's research underway now at Harvard Medical School
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Trenutno je u tijeku istraživanje u Medicinskoj školi na Harvardu
14:26
to pick the optimum pairs
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kako bi se izabrali optimalni parovi
14:28
to maximize that benefit.
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da bi se povećala korist.
14:30
We also believe that Tumor Treating Fields will work with radiation
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Također vjerujemo da će Polja za liječenje tumora surađivati sa zračenjem
14:33
and interrupt the self-repair mechanisms that we have.
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i prekidati mehanizam samopopravljanja koji imamo.
14:37
There's now a new research project underway
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Trenutno je u tijeku novi istraživački projekt
14:39
at the Karolinska in Sweden
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u Karolinskoj u Švedskoj
14:41
to prove that hypothesis.
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kako bi se dokazala ta tvrdnja.
14:43
We have more trials planned
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Imamo u planu još ispitivanja
14:45
for lung cancer,
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za rak pluća,
14:47
pancreatic cancer, ovarian cancer
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rak jetre, rak jajnika
14:49
and breast cancer.
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i rak dojke.
14:51
And I firmly believe
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I čvrsto vjerujem
14:53
that in the next 10 years
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kako će u sljedećih deset godina
14:55
Tumor Treating Fields
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Polja za liječenje tumora
14:57
will be a weapon available to doctors and patients
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biti oružje dostupno doktorima i pacijentima
15:00
for all of these most-difficult-to-treat solid tumors.
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za sve te najteže izlječive oblike tumora.
15:06
I'm also very hopeful
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Također se veoma nadam
15:08
that in the next decades,
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da ćemo u sljedećim desetljećima
15:10
we will make big strides
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napraviti velike korake
15:12
on reducing that death rate
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na smanjenju stope smrtnosti
15:15
that has been so challenging in this disease.
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u ovoj bolesti koja stvara tolike probleme.
15:18
Thank you.
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Hvala vam.
15:20
(Applause)
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(Pljesak)
ABOUT THE SPEAKER
Bill Doyle - EngineerWith his company Novocure, Bill Doyle works to bring breakthrough medical technologies to doctors and patients.
Why you should listen
Bill Doyle is the executive chair of Novocure, a company commercializing a new therapeutic modality for solid tumors using low-intensity electric fields. Recently, Novocure received FDA approval for its first indication, recurrent Glioblastoma Multiforme (GBM), the most virulent form of brain cancer; it is now conducting additional clinical trials.
In 2002, Doyle co-founded medical device venture firm WFD Ventures, which provides financing and business-building expertise to medical device companies with the potential to make a major impact on patient care, working with entrepreneurs, doctors and scientists to improve medical outcomes and maximize the potential of their innovations.
A graduate of MIT, Doyle stablished the MIT FIRST Scholarship for FIRST Robotics Competition participants admitted to MIT.
Watch Jay Walker's onstage Q&A with Bill Doyle >>
Bill Doyle | Speaker | TED.com