TEDxMidAtlantic
Hasini Jayatilaka: How cancer cells communicate -- and how we can slow them down
Hasini Đajatilaka (Hasini Jayatilaka): Kako ćelije raka komuniciraju - i kako da ih usporimo
Filmed:
Readability: 5.3
1,769,315 views
Kada su ćelije kancera zbijene jedna uz drugu u tumoru, u mogućnosti su da međusobno komuniciraju i usklade kretanje kroz telo. Šta ako bismo mogli da prekinemo ovaj proces? Ovim jednostavnim govorom o najnovijoj nauci, Hasini Đajatilaka predstavlja svoj rad na inovativnoj metodi zaustavljanja komunikacije među ćelijama kancera - i zaustavljanja njihove fatalne sposobnosti da se šire.
Hasini Jayatilaka - Cancer fighter
Hasini Jayatilaka discovered a novel mechanism that causes cancer cells to break away from tumors and metastasize. Full bio
Hasini Jayatilaka discovered a novel mechanism that causes cancer cells to break away from tumors and metastasize. Full bio
Double-click the English transcript below to play the video.
00:13
Cancer.
0
1111
1341
Rak.
00:14
It's a devastating disease
that takes an enormous emotional toll.
that takes an enormous emotional toll.
1
2476
4501
Razarajuća bolest
koja uzima ogroman emotivni danak.
koja uzima ogroman emotivni danak.
00:19
Not only on the patient,
but the patient's loved ones, as well.
but the patient's loved ones, as well.
2
7317
3897
Ne samo pacijentima,
već i njihovim voljenima.
već i njihovim voljenima.
00:24
It is a battle that the human race
has been fighting for centuries.
has been fighting for centuries.
3
12081
4301
To je bitka koju ljudi vode vekovima.
00:28
And while we've made some advancements,
4
16835
2833
I mada ima izvesnih pomaka,
00:31
we still haven't beaten it.
5
19692
2381
još ga nismo pobedili.
00:35
Two out of five people in the US
will develop cancer in their lifetime.
will develop cancer in their lifetime.
6
23033
5272
Dvoje od petoro ljudi u SAD-u
oboli od raka u toku života.
oboli od raka u toku života.
00:40
Of those, 90 percent will succumb
to the disease due to metastases.
to the disease due to metastases.
7
28890
4927
Od toga, 90% podlegne bolesti
zbog metastaza.
zbog metastaza.
00:46
Metastasis is a spread of cancer
from a primary site to a distal site,
from a primary site to a distal site,
8
34554
5523
Metastaza je širenje raka
sa primarnog na distalno područje,
sa primarnog na distalno područje,
00:52
through the circulatory
or the lymphatic system.
or the lymphatic system.
9
40101
3119
putem krvnog ili limfnog sistema.
00:55
For instance, a female patient
with breast cancer
with breast cancer
10
43879
3770
Na primer, pacijentkinja sa rakom dojke
00:59
doesn't succumb to the disease simply
because she has a mass on her breast.
because she has a mass on her breast.
11
47673
4134
ne podleže bolesti samo
jer ima masu na dojci.
jer ima masu na dojci.
01:04
She succumbs to the disease
because it spreads
because it spreads
12
52228
2794
Podleže bolesti
jer se bolest proširila
jer se bolest proširila
01:07
to the lungs, liver,
lymph nodes, brain, bone,
lymph nodes, brain, bone,
13
55046
4444
na pluća, jetru,
limfne čvorove, mozak, kosti,
limfne čvorove, mozak, kosti,
01:11
where it becomes unresectable
or untreatable.
or untreatable.
14
59514
3198
gde se ne može operisati ili lečiti.
01:15
Metastasis is a complicated process.
15
63927
2849
Metastaza je komplikovan proces.
01:18
One that I've studied
for several years now.
for several years now.
16
66800
2626
Proces koji izučavam
već nekoliko godina.
već nekoliko godina.
01:21
And something that my team
and I discovered recently
and I discovered recently
17
69879
3452
Moj tim i ja smo nedavno otkrili
01:25
was that cancer cells are able
to communicate with each other
to communicate with each other
18
73355
3754
da ćelije raka mogu
međusobno da komuniciraju
međusobno da komuniciraju
01:29
and coordinate their movement,
19
77133
2143
i koordinišu kretanja,
01:31
based on how closely packed they are
in the tumor microenvironment.
in the tumor microenvironment.
20
79300
4722
na osnovu toga koliko su zbijene
u mikrosredini tumora.
u mikrosredini tumora.
01:36
They communicate with each other
through two signaling molecules
through two signaling molecules
21
84887
3483
Međusobno komuniciraju preko
dva signalizirajuća molekula
dva signalizirajuća molekula
01:40
called Interleukin-6 and Interleukin-8.
22
88394
2670
koji se zovu Interleukin-6 i Interleukin-8.
01:43
Now, like anything else in nature,
23
91839
3071
Sad, kao sve ostalo u prirodi,
01:46
when things get a little too tight,
the signal is enhanced,
the signal is enhanced,
24
94934
4643
što su međusobno bliže, signal je jači,
01:51
causing the cancer cells
to move away faster from the primary site
to move away faster from the primary site
25
99601
4516
uzrokujući da kancerogene ćelije
brže putuju sa primarne lokacije
brže putuju sa primarne lokacije
01:56
and spread to a new site.
26
104141
2245
i šire se na nove.
01:59
So, if we block this signal,
using a drug cocktail that we developed,
using a drug cocktail that we developed,
27
107180
5715
Dakle, ako blokiramo ovaj signal,
koristeći koktel lekova koji smo razvili,
koristeći koktel lekova koji smo razvili,
02:04
we can stop the communication
between cancer cells
between cancer cells
28
112919
3674
možemo da zaustavimo komunikaciju
između kancerogenih ćelija
između kancerogenih ćelija
02:08
and slow down the spread of cancer.
29
116617
2682
i da usporimo širenje raka.
02:12
Let me pause here for a second
30
120514
1762
Da zastanemo ovde na trenutak
02:14
and take you back to when
this all began for me in 2010,
this all began for me in 2010,
31
122300
4801
i vratimo se u 2010.
kada je sve ovo započelo,
kada je sve ovo započelo,
02:19
when I was just a sophomore in college.
32
127125
2705
dok sam još bila na drugoj godini koledža.
02:22
I had just started working
in Dr Danny Wirtz's lab
in Dr Danny Wirtz's lab
33
130346
3406
Tek sam počela sa radom
u laboratoriji Dr Denija Virca
u laboratoriji Dr Denija Virca
02:25
at Johns Hopkins University.
34
133776
1866
na Univerzitetu Džons Hopkins.
02:28
And I'll be honest: I was a young,
naive, Sri Lankan girl,
naive, Sri Lankan girl,
35
136347
5325
Biću iskrena - bila sam mlada,
naivna Šrilankanka,
naivna Šrilankanka,
02:33
(Laughter)
36
141696
1159
(Smeh)
02:34
who had no previous research experience.
37
142879
3118
bez prethodnog istraživačkog iskustva.
02:38
And I was tasked
to look at how cancer cells move
to look at how cancer cells move
38
146537
3596
Moj zadatak je bio
da posmatram kretanje kancerogenih ćelija
da posmatram kretanje kancerogenih ćelija
02:42
in a 3D collagen I matrix
39
150157
2658
u 3D kolagen-1 matriksu
02:44
that recapsulated, in a dish,
40
152839
2389
koji je reprodukovao, u posudi,
02:47
the conditions that cancer cells
are exposed to in our bodies.
are exposed to in our bodies.
41
155252
4200
uslove kojima su kancerogene ćelije
izložene u našim telima.
izložene u našim telima.
02:52
This was new and exciting for me,
42
160117
1786
Ovo je za mene bilo novo i uzbudljivo,
02:53
because previous work had been done
on 2D, flat, plastic dishes
on 2D, flat, plastic dishes
43
161927
5023
jer je prethodno rađeno na 2D,
ravnim, plastičnim posudama,
ravnim, plastičnim posudama,
02:58
that really weren't representative
44
166974
2555
koje nisu verno predstavljale uslove
03:01
of what the cancer cells
are exposed to in our bodies.
are exposed to in our bodies.
45
169553
3667
kojima su kancerogene ćelije
izložene u našim telima.
izložene u našim telima.
03:05
Because, let's face it,
46
173665
2286
Jer, budimo realni,
03:07
the cancer cells in our bodies
aren't stuck onto plastic dishes.
aren't stuck onto plastic dishes.
47
175975
4173
ćelije kancera u našim telima
nisu zalepljene na plastične posude.
nisu zalepljene na plastične posude.
03:13
It was during this time
that I attended a seminar
that I attended a seminar
48
181006
3277
Istovremeno sam pohađala seminar
03:16
conducted by Dr Bonnie Bassler
from Princeton University,
from Princeton University,
49
184307
4040
koji je vodila Dr Boni Basler
sa Prinston Univerziteta,
sa Prinston Univerziteta,
03:20
where she talked about how bacteria cells
communicate with each other,
communicate with each other,
50
188371
4666
gde je govorila kako ćelije bakterija
međusobno komuniciraju,
međusobno komuniciraju,
03:25
based on their population density,
and perform a specific action.
and perform a specific action.
51
193061
4193
na osnovu gustine populacije,
i izvode izvesne radnje.
i izvode izvesne radnje.
03:30
It was at this moment that a light bulb
went off in my head, and I thought,
went off in my head, and I thought,
52
198236
4949
U tom trenutku mi se upalila lampica,
i pomislila sam,
i pomislila sam,
03:35
"Wow, I see this
in my cancer cells every day,
in my cancer cells every day,
53
203209
3532
"Oho, ovo vidim u mojim ćelijama
kancera svakodnevno,
kancera svakodnevno,
03:38
when it comes to their movement."
54
206765
1714
kada posmatram njihovo kretanje."
03:40
The idea for my project was thus born.
55
208908
2682
I tako je nastala ideja za moj projekat.
03:44
I hypothesized that cancer cells
are able to communicate with each other
are able to communicate with each other
56
212307
4992
Postavila sam hipotezu da ćelije kancera
mogu međusobno da komuniciraju
mogu međusobno da komuniciraju
03:49
and coordinate their movement,
57
217323
2190
i koordinišu svoje kretanje,
03:51
based on how closely packed they are
in the tumor microenvironment.
in the tumor microenvironment.
58
219537
4286
na osnovu toga koliko su gusto zbijene
u mikrosredini tumora.
u mikrosredini tumora.
03:57
I became obsessed with pursuing
this hypothesis.
this hypothesis.
59
225220
3523
Postala sam opsednuta
dokazivanjem ove hipoteze.
dokazivanjem ove hipoteze.
04:01
And fortunately, I work for someone
60
229243
2787
I srećom, radim za nekoga
04:04
who is open to running
with my crazy ideas.
with my crazy ideas.
61
232054
2880
ko je otvoren da sasluša moje lude ideje.
04:07
So, I threw myself into this project.
62
235466
2658
I tako sam se bacila na ovaj projekat.
04:10
However, I couldn't do it by myself.
63
238665
2856
Ipak, nisam mogla da ga uradim sama.
04:13
I needed help.
64
241958
1150
Trebala mi je pomoć.
04:15
I definitely needed help.
65
243442
1611
Definitivno mi je trebala pomoć.
04:17
So we recruited undergraduate
students, graduate students,
students, graduate students,
66
245593
3222
Te smo regrutovali redovne studente,
diplomirane studente,
diplomirane studente,
04:20
postdoctoral fellows and professors
67
248839
2595
doktore nauka i profesore
04:23
from different institutions
and multiple disciplines
and multiple disciplines
68
251458
3889
iz raznih institucija i raznovrsnih disciplina
04:27
to come together and work on this idea
69
255371
3114
da se skupe i sarađuju na ovoj ideji
04:30
that I conceived
as a sophomore in college.
as a sophomore in college.
70
258509
2933
koju sam smislila
na drugoj godini koledža.
na drugoj godini koledža.
04:33
After years of conducting
experiments together
experiments together
71
261935
3303
Nakon godina izvođenja
eksperimenata zajedno
eksperimenata zajedno
04:37
and merging different ideas
and perspectives,
and perspectives,
72
265262
3532
i sastavljanja različitih ideja
i perspektiva,
i perspektiva,
04:40
we discovered a new signaling pathway
73
268818
3323
otkrili smo novu signalnu putanju
04:44
that controls how cancer cells
communicate with each other and move,
communicate with each other and move,
74
272165
5095
koja kontroliše kako ćelije kancera
komuniciraju međusobno i kako se kreću,
komuniciraju međusobno i kako se kreću,
04:49
based on their cell density.
75
277284
1866
na osnovu njihove ćelijske gustine.
04:52
Some of you might have heard this,
76
280331
1684
Neki među vama su možda već čuli,
04:54
because most of social media knows it
as the Hasini effect.
as the Hasini effect.
77
282039
4348
jer je u društvenim medijima poznato
kao Hasini efekat.
kao Hasini efekat.
04:58
(Laughter)
78
286411
2818
(Smeh)
05:01
(Applause)
79
289253
6181
(Aplauz)
05:08
And we weren't done yet.
80
296280
1690
Ali mi nismo još završili.
05:09
We then decided that we wanted
to block this signaling pathway
to block this signaling pathway
81
297994
4024
Odlučili smo potom da želimo
da blokiramo ovu signalnu putanju
da blokiramo ovu signalnu putanju
05:14
and see if we could slow down
the spread of cancer.
the spread of cancer.
82
302042
2960
i probamo da usporimo širenje raka.
05:17
Which we did, in preclinical
animal models.
animal models.
83
305307
2671
Što smo i uspeli, u pretkliničkim
životinjskim modelima.
životinjskim modelima.
05:20
We came up with a drug cocktail
consisting of tocilizumab,
consisting of tocilizumab,
84
308458
4071
Smislili smo koktel lekova
koji se sastoji od tocilizumaba,
koji se sastoji od tocilizumaba,
05:24
which is currently used to treat
rheumatoid arthritis,
rheumatoid arthritis,
85
312553
2985
koji se trenutno koristi za lečenje
reumatoidnog artritisa,
reumatoidnog artritisa,
05:27
and reparixin, which is currently
in clinical trials against breast cancer.
in clinical trials against breast cancer.
86
315562
4878
i repariksina, koji se trenutno
klinički ispituje protiv kancera dojke.
klinički ispituje protiv kancera dojke.
05:33
And interestingly, what we found
was that this cocktail of drugs
was that this cocktail of drugs
87
321061
4937
Zanimljivo je da smo otkrili
da ovaj koktel lekova
da ovaj koktel lekova
05:38
really had no effect on tumor growth,
88
326022
2578
nije imao efekta na rast tumora,
05:40
but directly targeted metastases.
89
328624
2603
ali je direktno ciljao metastaze.
05:43
This was a significant finding,
90
331982
2778
Ovo je bilo bitno otkriće,
05:46
because currently, there aren't any
FDA-approved therapeutics
FDA-approved therapeutics
91
334784
4269
jer trenutno, ne postoji nijedna
FDA odobrena terapija
FDA odobrena terapija
05:51
that directly target the spread of cancer.
92
339077
2619
koja direktno cilja širenje raka.
05:54
In fact, the spread of cancer, metastasis,
93
342149
3487
Zapravo, širenje raka - metastaze,
05:57
is thought of as a byproduct
of tumor growth.
of tumor growth.
94
345660
3103
se smatra sporednim
proizvodom rasta tumora.
proizvodom rasta tumora.
06:01
Where the idea is, if we can stop
the tumor from growing,
the tumor from growing,
95
349168
3794
Osnovna zamisao je da, ako možemo
da zaustavimo rast tumora,
da zaustavimo rast tumora,
06:04
we can stop the tumor from spreading.
96
352986
2734
možemo da zaustavimo širenje tumora.
06:07
However, most of us know
that this is not true.
that this is not true.
97
355744
4126
Ipak, većina nas zna da ovo nije istina.
06:12
We, on the other hand,
came up with the drug cocktail
came up with the drug cocktail
98
360776
3706
Mi smo, sa druge strane,
osmislili koktel lekova
osmislili koktel lekova
06:16
that targets metastasis
not by targeting tumor growth,
not by targeting tumor growth,
99
364506
4079
koji cilja metastaze
ne ciljajući rast tumora,
ne ciljajući rast tumora,
06:20
but by targeting the complex
mechanisms that govern it,
mechanisms that govern it,
100
368609
3667
već ciljajući kompleksne mehanizme
kojim se upravlja,
kojim se upravlja,
06:24
through the targeting
of the Hasini effect.
of the Hasini effect.
101
372300
3147
ciljanjem Hasini efekta.
06:27
(Laughter)
102
375471
1150
(Smeh)
06:29
This work was recently published
in "Nature Communications,"
in "Nature Communications,"
103
377244
4271
Ovaj rad je nedavno objavljen u
"Komunikacijama prirode".
"Komunikacijama prirode".
06:33
and my team and I received an overwhelming
response from around the world.
response from around the world.
104
381539
5000
Moj tim i ja smo obasuti
brojnim odgovorima sa raznih strana sveta.
brojnim odgovorima sa raznih strana sveta.
06:38
Nobody on my team could have predicted
this sort of response.
this sort of response.
105
386950
3960
Niko u mom timu nije mogao
predvideti ovakav odgovor.
predvideti ovakav odgovor.
06:42
We seem to have struck a nerve.
106
390934
1933
Izgleda da smo udarili pravo u živac.
06:45
Looking back, I am extremely grateful
for the positive response that I received,
for the positive response that I received,
107
393267
5506
U retrospektivi, ekstremno sam zahvalna
za pozitivne odgovore koje sam primila,
za pozitivne odgovore koje sam primila,
06:50
not only from academia, but also patients,
108
398797
3064
ne samo od akademika, već i od pacijenata,
06:53
and people around the world
affected by this terrible disease.
affected by this terrible disease.
109
401885
3932
i ljudi širom sveta
koji su pogođeni ovom užasnom bolešću.
koji su pogođeni ovom užasnom bolešću.
06:58
As I reflect on this success
I've encountered with the Hasini effect,
I've encountered with the Hasini effect,
110
406807
5096
Dok razmišljam o uspehu
na koji sam naišla sa Hasini efektom,
na koji sam naišla sa Hasini efektom,
07:03
I keep coming back to the people
that I was fortunate enough to work with.
that I was fortunate enough to work with.
111
411927
4766
stalno se vraćam na ljude
sa kojima sam imala sreće da sarađujem.
sa kojima sam imala sreće da sarađujem.
07:09
The undergraduate students
112
417678
1636
Redovni studenti
07:11
who demonstrated superhuman powers
through their hard work and dedication.
through their hard work and dedication.
113
419338
5106
koji su pokazali nadljudske moći
kroz naporan rad i posvećenost.
kroz naporan rad i posvećenost.
07:16
The graduate students
and the postdoctoral fellows,
and the postdoctoral fellows,
114
424886
3350
Diplomirani studenti i doktori nauka,
07:20
my fellow Avengers,
who taught me new techniques
who taught me new techniques
115
428260
3548
moji partneri Osvetnici,
koji su me naučili novim tehnikama
koji su me naučili novim tehnikama
07:23
and always made sure I stayed on track.
116
431832
2600
i uvek vodili računa
da ostanem na pravom putu.
da ostanem na pravom putu.
07:26
The professors, my Yodas
and my Obi-Wan Kenobis,
and my Obi-Wan Kenobis,
117
434950
4310
Profesori, moje Jode
i moji Obii Van Kenobii,
i moji Obii Van Kenobii,
07:31
who brought their expertise into
making this work into what it is today.
making this work into what it is today.
118
439284
5136
koji su svojom ekspertizom doprineli
da ovaj rad postane ono što jeste.
da ovaj rad postane ono što jeste.
07:37
The support staff, the friends and family,
119
445371
3198
Pomoćno osoblje, prijatelji i porodica,
07:40
people who lifted our spirits,
120
448593
2540
ljudi koji su nas bodrili,
07:43
and never let us give up
on our ambitious endeavors.
on our ambitious endeavors.
121
451157
3533
i nisu nikada dozvolili da odustanemo
od naših ambicioznih nastojanja.
od naših ambicioznih nastojanja.
07:47
The best kind of sidekicks
we could have asked for.
we could have asked for.
122
455196
3151
Najbolja podrška koju smo mogli zamisliti.
07:50
It took a village to help me
study metastasis.
study metastasis.
123
458966
3067
Trebalo je jedno celo selo
da mi pomogne u izučavanju metastaza.
da mi pomogne u izučavanju metastaza.
07:54
And believe me, without my village,
I wouldn't be here.
I wouldn't be here.
124
462347
3713
I verujte mi, bez mog sela,
ne bih bila ovde.
ne bih bila ovde.
07:59
Today, our team has grown,
125
467205
2444
Danas, naš tim je narastao,
08:01
and we are using the Hasini effect
to develop combination therapies
to develop combination therapies
126
469673
4658
i koristimo Hasini efekat
da razvijemo kombinovane terapije
da razvijemo kombinovane terapije
08:06
that will effectively target
tumor growth and metastases.
tumor growth and metastases.
127
474355
4079
koje će efikasno ciljati
rast tumora i metastaze.
rast tumora i metastaze.
08:10
We are engineering
new anticancer therapeutics,
new anticancer therapeutics,
128
478458
3365
Stvaramo nove antikancerogene terapije,
08:13
to limit toxicity and to reduce
drug resistance.
drug resistance.
129
481847
3635
da ograničimo toksičnost
i smanjimo otpornost na lekove.
i smanjimo otpornost na lekove.
08:17
And we are developing
groundbreaking systems
groundbreaking systems
130
485958
3302
I razvijamo revolucionarne sisteme
08:21
that will help for the development
of better human clinical trials.
of better human clinical trials.
131
489284
4250
koji će pomoći u razvoju
boljih kliničkih ispitivanja na ljudima.
boljih kliničkih ispitivanja na ljudima.
08:26
It blows my mind to think that all this,
132
494474
4405
Ostajem bez daha kad pomislim da sve ovo,
08:30
the incredible work that I'm pursuing --
133
498903
2755
neverovatan rad kojim se bavim -
08:33
and the fact that I'm standing here,
talking to you today --
talking to you today --
134
501682
3151
i činjenica da stojim ovde,
govorim pred vama danas -
govorim pred vama danas -
08:36
all came from this tiny idea
135
504857
3167
sve je nastalo iz ove malene ideje
08:40
that I had when I was sitting
at the back of a seminar
at the back of a seminar
136
508048
2960
koja mi je sinula
u zadnjim redovima na seminaru
u zadnjim redovima na seminaru
08:43
when I was just 20 years old.
137
511032
1933
kada mi je bilo samo 20 godina.
08:46
I recognize that right now,
I am on this incredible journey
I am on this incredible journey
138
514325
4389
Shvatam sada da sam
na neverovatnom putovanju
na neverovatnom putovanju
08:50
that allows me to pursue work
that I am extremely passionate about,
that I am extremely passionate about,
139
518738
4260
koje mi dopušta da se bavim radom
za koji posedujem ogromnu strast,
za koji posedujem ogromnu strast,
08:55
and something that feeds
my curiosity on a daily basis.
my curiosity on a daily basis.
140
523022
3983
i koji svakodnevno pothranjuje
moju radoznalost.
moju radoznalost.
08:59
But I have to say,
my favorite part of all of this --
my favorite part of all of this --
141
527879
5099
Ali moram reći,
moj omiljeni deo svega ovog je -
moj omiljeni deo svega ovog je -
09:05
other than, of course, being here,
talking to you, today --
talking to you, today --
142
533002
3007
sem, naravno, što sam ovde,
i govorim pred vama, danas -
i govorim pred vama, danas -
09:08
is the fact that I get to work
with a diverse group of people,
with a diverse group of people,
143
536033
4933
činjenica da sarađujem
sa raznolikom grupom ljudi,
sa raznolikom grupom ljudi,
09:12
who make my work stronger,
better and just so much more fun.
better and just so much more fun.
144
540990
5912
koji čine moj rad jačim,
boljim i zabavnijim.
boljim i zabavnijim.
09:19
And because of this, I have to say
145
547694
2698
I zbog toga, moram da kažem da je
09:22
that collaboration is my favorite
superhuman power.
superhuman power.
146
550416
3682
saradnja moja omiljena nadljudska moć.
09:26
And what I love about this power
is that it's not unique to me.
is that it's not unique to me.
147
554940
4451
Volim što nije svojstvena samo meni.
09:31
It's within all of us.
148
559415
1634
Postoji u svima nama.
09:33
My work shows that even cancer cells
149
561700
3223
Moj rad dokazuje da čak i ćelije kancera
09:36
use collaboration to invade our bodies
and spread their wrath.
and spread their wrath.
150
564947
4301
koriste saradnju da napadnu naša tela
i šire svoju srdžbu.
i šire svoju srdžbu.
09:41
For us humans, it is a superpower
that has produced incredible discoveries
that has produced incredible discoveries
151
569958
5198
Za nas ljude, to je supermoć
koja je stvorila neverovatna otkrića
koja je stvorila neverovatna otkrića
09:47
in the medical and scientific field.
152
575180
2400
u poljima medicine i nauke.
09:49
And it is the superpower
that we can all turn to
that we can all turn to
153
577958
3405
I to je supermoć
kojoj se svi možemo okrenuti
kojoj se svi možemo okrenuti
09:53
to inspire us to create
something bigger than ourselves,
something bigger than ourselves,
154
581387
3690
u potrazi za inspiracijom da stvorimo
nešto veće od nas samih,
nešto veće od nas samih,
09:57
that will help make
the world a better place.
the world a better place.
155
585101
3067
što će pomoći da učini svet boljim.
10:00
Collaboration is the superpower
that I turn to, to help me fight cancer.
that I turn to, to help me fight cancer.
156
588641
5529
Saradnja je supermoć kojoj se priklanjam,
da mi pomogne da pobedim rak.
da mi pomogne da pobedim rak.
10:06
And I am confident
that with the right collaborations,
that with the right collaborations,
157
594702
3960
I sigurna sam da ćemo uz prave saradnje,
10:10
we will beat this terrible disease.
158
598686
2334
pobediti ovu užasnu bolest.
10:13
Thank you.
159
601678
1151
Hvala.
10:14
(Applause)
160
602853
3424
(Aplauz)
ABOUT THE SPEAKER
Hasini Jayatilaka - Cancer fighterHasini Jayatilaka discovered a novel mechanism that causes cancer cells to break away from tumors and metastasize.
Why you should listen
Hasini Jayatilaka is postdoctoral fellow at Stanford University focused on elucidating mechanisms that govern relapse in childhood cancers, particularly B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and neuroblastoma.
BCP-ALL is a common childhood malignancy that has seen dramatic improvements in survival using current treatment regimens. However, relapse is the most frequent cause of cancer-related death among children with BCP-ALL. Jayatilaka is studying the activation of pro-survival and drug resistance mechanisms in a subset of the BCP-ALL population that allow tumor cells to persist following treatment and cause relapse.
Jayatilaka is currently conducting research on understanding the complex pathways that govern metastasis, the spread of cancer, which is responsible for 90% of cancer related deaths. She recently discovered a new signaling pathway that controls metastasis and showed that by blocking the pathway, the spread of cancer can be slowed down.
Jayatilaka grew up in Sri Lanka and pursued her BS and PhD in Chemical and Bimolecular Engineering at Johns Hopkins University.
Hasini Jayatilaka | Speaker | TED.com