Sangeeta Bhatia: This tiny particle could roam your body to find tumors
Sangeeta Bhatia - Physician, bioengineer and entrepreneur
Sangeeta Bhatia is a cancer researcher, MIT professor and biotech entrepreneur who works to adapt technologies developed in the computer industry for medical innovation. Full bio
to house one transistor,
the size of an entire room
revolution in computers.
to reduce the number of lives lost
diseases on Earth:
is that we're working on curing cancer.
opportunity to save lives
and prevention of cancer.
due to cancer are fully preventable
have in hand today.
and technologies that we have today,
they've started growing,
cancer cells strong.
deadly cancers sooner,
miniaturization might get us there.
for looking at a tissue specimen,
with years of specialized training
of mine at Rice University,
is miniaturize that whole microscope
of an optical fiber.
of taking a sample from a patient
to the patient.
a specialist to look at the images,
normal versus cancerous cells.
working in rural communities,
a mobile screening van
and perform exams
hospital for analysis,
with an abnormal test result
because they can't afford the trip.
and computer analysis,
have been able to create a van
and a treatment setup.
is that they can do a diagnosis
miniaturization can save lives.
as straight-up miniaturization.
and you made it little.
for us to take them everywhere.
equivalent like that in medicine?
circulate in your body,
like science fiction.
allows us to do just that.
the parts that make up the detector
actually change their properties
into gold nanoparticles,
gold to looking red.
like cadmium selenide --
out of this material
yellow, orange, red,
like that in the macro world?
in your closet are all made of cotton,
depending only on their size.
the color of materials
in your body also changes.
that we're going to use
into the blood vessel
from the bloodstream into the tumor.
of many tumors are leaky,
from the bloodstream into the tumor.
depends on their size.
blue nanoparticles are leaking out,
or small I make a material,
a cancer nanodetector
into the body and look for tumors.
for tumor invasion:
that tumors need to make to spread.
of the tissue that it's born in,
the scaffolding of tissues.
to be activated by these enzymes.
of these chemical reactions in an hour.
that one-to-a-thousand ratio
signal to the outside world,
one more piece of nanoscale biology,
and put waste into the urine.
than five nanometers
through the kidney, into the urine,
that's bigger is retained.
where it's activated by tumor enzymes
filtered out of the kidney
that I can detect.
that we designed as engineers.
and we can design them
with our tool of choice.
sensitive, fancy instrument
with a unique mass.
that's more inexpensive and portable.
that we can trap on paper,
world of paper tests
in a field called paper diagnostics.
to keep us pushing forward,
will happen with my technology,
our hearts and souls
an expensive screening facility
on a smartphone.
have this working in mice,
than existing methods
colon and ovarian cancer.
detect tumors in patients
after they've started growing,
to earlier treatments,
than we can today,
About the speaker:Sangeeta Bhatia - Physician, bioengineer and entrepreneur
Sangeeta Bhatia is a cancer researcher, MIT professor and biotech entrepreneur who works to adapt technologies developed in the computer industry for medical innovation.
Why you should listen
Trained as both a physician and engineer at Harvard, MIT, and Brown University, Sangeeta Bhatia leverages 'tiny technologies' of miniaturization to yield inventions with new applications in tissue regeneration, stem cell differentiation, medical diagnostics, predictive toxicology and drug delivery. She and her trainees have launched more than 10 biotechnology companies to improve human health.
Bhatia has received many honors including the Lemelson-MIT Prize, known as the 'Oscar for inventors,' and the Heinz Medal for groundbreaking inventions and advocacy for women in STEM fields. She is a Howard Hughes Medical Institute Investigator, the Director of the Marble Center for Cancer Nanomedicine at the Koch Institute for Integrative Cancer Research and an elected member of the National Academy of Engineering, the American Academy of Arts and Science and Brown University's Board of Trustees.
Sangeeta Bhatia | Speaker | TED.com