Tony Wyss-Coray: How young blood might help reverse aging. Yes, really
Tony Wyss-Coray - Brain scientist
At his lab at Stanford School of Medicine, Tony Wyss-Coray studies aging -- and potential cures for it. Full bio
from Lucas Cranach the Elder.
you will get health and youth.
has dreamed of finding eternal youth.
or Ponce De León, the explorer,
chasing the Fountain of Youth.
to this Fountain of Youth?
development in aging research
the way we think about aging
diseases in the future.
of studies about growing,
that share a blood supply with young mice
in humans, in Siamese twins,
researcher, reported in 2007,
can be rejuvenated
through common circulation.
at Harvard a few years later,
rejuvenating effects could be observed
and several other labs as well,
exposed to a young environment
through shared circulation
younger in its brain.
of human cognition,
verbal ability and so forth.
these functions are all intact,
here in the room, we're all still fine.
how all these curves go south.
and others may develop.
the connections between neurons --
the synapses -- they start to deteriorate;
for these neurodegenerative diseases.
to understand how this really works
in detail, in living people.
we can do imaging --
until the person dies
changed through age or in a disease.
do, for example.
as being part of the larger organism.
at the molecular level
as part of the entire body?
does that affect the brain?
does that influence the rest of the body?
tissues in the body
cells that transport oxygen, for example,
that transport information
from one tissue to another,
changes in disease or age,
the blood changes as well,
change as we get older.
factors that we know are required
for the maintenance of tissues --
in injury and in inflammation --
and bad factors, if you will.
potentially with that,
an experiment that we did.
from healthy human beings
of these communication factors,
transport information between tissues.
and the oldest group,
different environment as we get older,
or bioinformatics programs,
those factors that best predict age --
the relative age of a person.
is shown in this graph.
the actual age a person lived,
that I showed you,
their biological age.
there is a pretty good correlation,
the relative age of a person.
are the outliers,
I highlighted with the green dot
if what we're doing here is really true,
looks much younger than their age?
who is maybe at a reduced risk
and will have a long life --
highlighted with the red dot,
but has a biological age of 65.
of developing an age-related disease?
to understand these factors better,
are trying to understand,
to possibly predict age-related diseases?
is simply correlational, right?
"Well, these factors change with age,"
if they do something about aging.
is very remarkable
can actually modulate the age of a tissue.
to this model called parabiosis.
the two mice together,
to a shared blood system,
"How does the old brain get influenced
of 20-year-old people,
65 years old in human years.
that make new neurons
activity of the synapses,
that are known to be involved
entering the brains of these animals.
going into the old brain, in this model.
that it must be the soluble factors,
fraction of blood which is called plasma,
or old plasma into these mice,
these rejuvenating effects,
they have memory problems.
how we do that.
one step further,
being relevant to humans.
are unpublished studies,
young human plasma,
rejuvenate these old mice?
It's called a Barnes maze.
that has lots of holes in it,
as on this stage here.
pointed at with an arrow,
and feel comfortable in a dark hole.
on these cues in the space,
after a busy day of shopping.
some problems with that.
that has memory problems,
but it didn't form this spacial map
in the previous trial or the last day.
is a sibling of the same age,
human plasma for three weeks,
looks around, "Where am I?" --
to that hole and escapes.
seems to be rejuvenated --
that there is something
but in young human plasma
to help this old brain.
in particular, are malleable.
we can actually change them.
suffers from exposure to the old.
that can accelerate aging.
humans may have similar factors,
blood and have a similar effect.
does not have this effect;
clinical study at Stanford,
with mild disease
from young volunteers, 20-year-olds,
at their brains with imaging.
for daily activities of living.
some signs of improvement
that could give us hope
is actually within us,
back on a little bit,
that are mediating these effects,
such as Alzheimer's disease
About the speaker:Tony Wyss-Coray - Brain scientist
At his lab at Stanford School of Medicine, Tony Wyss-Coray studies aging -- and potential cures for it.
Why you should listen
Professor of neurology at Stanford, Tony Wyss-Coray oversees an eponymous lab which studies immune and injury responses in aging and neurodegeneration.
Wyss-Coray initially studied at the Institute of Clinical Immunology at the University of Bern in Switzerland, but he now lives and works in California. At Stanford since 2002, he's also a health scientist at the Veterans Affairs Palo Alto Health Care System. Deeply interested in figuring out ways to combat diseases such as Alzheimer's, he serves on the scientific advisory board for the Alzheimer Research Consortium and on the international advisory board for Advances in Clinical and Experimental Medicine. In 2013, he was given a Transformative Research Award by the director of the National Institutes of Health.
Tony Wyss-Coray | Speaker | TED.com