ABOUT THE SPEAKER
Laura Indolfi - Biomedical entrepreneur
Laura Indolfi is revolutionizing cancer treatment with new technologies including implantable devices for delivering drugs locally to the site of a tumor.

Why you should listen

Laura Indolfi is a biomedical entrepreneur, CEO and co-founder of PanTher Therapeutics, an early stage spin-out from MIT and MGH that provides superior technologies for revolutionizing the treatment of locally advanced inoperable solid tumors. Prior to this she served as an entrepreneur-in-residence at the MGH Cancer Center and as a research associate in the Harvard-MIT Institute for Medical Engineering and Science. She was selected as a TED Fellow in 2016.

Indolfi has broad professional experiences and interests ranging from biomedical engineering to entrepreneurship and outreaching initiative to promoting science. Her scientific expertise covers a broad range of therapeutic areas (cardio, cancer, inflammation, regenerative medicine) and approaches (drug delivery, cell therapy, implanted devices). Together with her strong technical background, Laura has hands-on business and managerial know-how developed during her biomedical business training at Sloan and Harvard Business Schools and with several consulting firms. She strongly believes in the power of outreach initiatives to promote research awareness and foster the public audience's discovery of the beauty of science. In 2014 the line of clothes Cytocouture, created in collaboration with Colombian designer Carlos Villamil and inspired by her cell-therapy research, won the global competition Descience.

Indolfi holds a MS/BS degree in materials science and engineering and a PhD in biomaterials from the University of Naples Federico II in Italy. Upon graduation, she joined the Harvard-MIT Division of health, science and technology, working on several projects spanning from devices for local drug delivery to tissue engineering approaches for cell therapies.

More profile about the speaker
Laura Indolfi | Speaker | TED.com
TED2016

Laura Indolfi: Good news in the fight against pancreatic cancer

Laura Indolfi: 治疗胰腺癌的福音

Filmed:
1,319,228 views

任何一个人如果有亲人死于胰腺癌,都知道胰腺癌对于一个其他方面都健康的人损害速度有快。Laura Indolfi,TED伙伴、生物医学企业家,正致力于研发一种革新的方式来治疗这个复杂且致命的疾病:一种给药装置,它置于肿瘤上能像笼子一样阻止肿瘤扩散,并能将药物只作用于需要的地方。“我们希望,有一天我们能使胰腺癌成为一种可治愈的疾病”,她说。
- Biomedical entrepreneur
Laura Indolfi is revolutionizing cancer treatment with new technologies including implantable devices for delivering drugs locally to the site of a tumor. Full bio

Double-click the English transcript below to play the video.

在座各位
00:14
By raising提高 your hand,
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知道至少一个屏幕中所示的人,请举手
00:15
how many许多 of you know
at least最小 one person on the screen屏幕?
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哇,基本上每个人都举手了
00:20
Wow, it's almost几乎 a full充分 house.
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没错,他们在各自的领域都十分有名
00:22
It's true真正, they are very famous著名
in their fields领域.
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00:24
And do you know what
all of them have in common共同?
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你们知道他们有什么共同点吗?
00:27
They all died死亡 of pancreatic cancer癌症.
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他们都死于胰腺癌
00:30
However然而, although虽然 it's very,
very sad伤心 this news新闻,
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尽管这特别特别可悲
00:33
it's also thanks谢谢 to their personal个人 stories故事
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但也正是由于他们的自身经历
00:36
that we have raised上调 awareness意识
of how lethal致命 this disease疾病 can be.
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让我们意识到胰腺癌有多致命
00:40
It's become成为 the third第三 cause原因
of cancer癌症 deaths死亡,
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胰腺癌已成为癌症致死的第三大原因
00:43
and only eight percent百分 of the patients耐心
will survive生存 beyond five years年份.
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病人的五年及以上存活率只有百分之八
00:49
That's a very tiny number,
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这个比例是极小的
尤其是和存活率接近90%的乳腺癌相比
00:51
especially特别 if you compare比较 it
with breast乳房 cancer癌症,
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00:53
where the survival生存 rate
is almost几乎 90 percent百分.
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所以,被诊断得了胰腺癌
00:57
So it doesn't really come as a surprise
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01:00
that being存在 diagnosed确诊
with pancreatic cancer癌症
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意味着几乎是被判了死刑
这也就不足为怪了
01:02
means手段 facing面对 an almost几乎
certain某些 death死亡 sentence句子.
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01:06
What's shocking触目惊心, though虽然,
is that in the last 40 years年份,
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然而,让人震惊的是
在过去的40年,这个数字一点都没有变
01:09
this number hasn't有没有 changed a bit,
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01:12
while much more progress进展 has been made制作
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而其它肿瘤的治疗已经有了长足进步
01:14
with other types类型 of tumors肿瘤.
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01:16
So how can we make pancreatic cancer癌症
treatment治疗 more effective有效?
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那么我们该如何让胰腺癌治疗更有效呢?
01:20
As a biomedical生物医药 entrepreneur企业家,
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作为一名生物医学企业家
01:22
I like to work on problems问题
that seem似乎 impossible不可能,
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我希望去解决那些看起来不可能解决的问题
01:25
understanding理解 their limitations限制
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了解那些问题的限制因素
01:27
and trying to find new,
innovative创新 solutions解决方案
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并找到新的、创新的解决方案
01:30
that can change更改 their outcome结果.
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去改变结果
01:33
The first piece of bad news新闻
with pancreatic cancer癌症
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第一个关于胰腺癌的坏消息是
01:35
is that your pancreas胰腺 is in the middle中间
of your belly肚皮, literally按照字面.
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胰腺正好位于腹部的中间位置
01:39
It's depicted描绘 in orange橙子 on the screen屏幕.
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如屏幕上橙色部分所示
01:41
But you can barely仅仅 see it
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但是如果我不把胰腺前面的其它器官移开
01:43
until直到 I remove去掉 all the other
organs器官 in front面前.
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你几乎看不到它
01:47
It's also surrounded包围
by many许多 other vital重要 organs器官,
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而且它被很多其它重要的器官包围着
01:50
like the liver, the stomach,
the bile胆汁 duct.
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譬如肝、胃、胆管
01:53
And the ability能力 of the tumor
to grow增长 into those organs器官
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肿瘤会扩散到这些器官
01:56
is the reason原因 why pancreatic cancer癌症
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这也胰腺癌是最痛苦的肿瘤之一的原因
01:58
is one of the most painful痛苦 tumor types类型.
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另外,胰腺难以企及的位置
02:02
The hard-to-reach难以到达的 location位置
also prevents防止 the doctor医生
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使得医生很难采取例行的治疗方式
02:05
from surgically手术 removing去除 it,
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02:07
as is routinely常规 doneDONE
for breast乳房 cancer癌症, for example.
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例如对肺癌,通过手术摘除肿瘤
上述各种原因
02:10
So all of these reasons原因 leave离开
chemotherapy化疗 as the only option选项
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使得化疗成为了胰腺癌患者的唯一选择
02:14
for the pancreatic cancer癌症 patient患者.
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第二个坏消息是
02:16
This brings带来 us to the second第二
piece of bad news新闻.
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胰腺癌肿瘤的血管极少
02:19
Pancreatic cancer癌症 tumors肿瘤 have
very few少数 blood血液 vessels船只.
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02:23
Why should we care关心
about the blood血液 vessel船只 of a tumor?
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为什么我们要关心肿瘤的血管呢?
02:27
Let's think for a second第二
how chemotherapy化疗 works作品.
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让我们想想化疗的过程
药物被注入静脉
02:30
The drug药物 is injected注射 in the vein静脉
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然后流遍整个身体直到到达肿瘤处
02:32
and it navigates可前往[ throughout始终 the body身体
until直到 it reaches到达 the tumor site现场.
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02:37
It's like driving主动 on a highway高速公路,
trying to reach达到 a destination目的地.
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这就像在高速路上行驶
努力到达目的地一样
如果你的目的地在高速路上没有出口怎么办?
02:42
But what if your destination目的地
doesn't have an exit出口 on the highway高速公路?
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02:45
You will never get there.
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你将永远到不了目的地
02:47
And that's exactly究竟 the same相同 problem问题
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对于化疗和胰腺癌来说也一样
02:49
for chemotherapy化疗 and pancreatic cancer癌症.
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药物流遍你的整个身体
02:53
The drugs毒品 navigate导航
throughout始终 all of your body身体.
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02:55
They will reach达到 healthy健康 organs器官,
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它们进入了健康器官
给病人整体带来很高的毒副作用
02:58
resulting造成 in high toxic有毒的 effect影响
for the patients耐心 overall总体,
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但是极少药物作用到肿瘤
03:02
but very little will go to the tumor.
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因此治疗效果很有限
03:04
Therefore因此, the efficacy功效 is very limited有限.
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我认为,为了治疗某一个器官而对全身采取治疗
03:08
To me, it seems似乎 very counterintuitive有悖常理
to have a whole-body全身 treatment治疗
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是非常有悖常理的
03:13
to target目标 a specific具体 organ器官.
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03:15
However然而, in the last 40 years年份,
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然而,在过去的40年里
大量的金钱、研究、努力被投入到
03:18
a lot of money, research研究
and effort功夫 have gone走了 towards
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03:22
finding发现 new, powerful强大 drugs毒品
to treat对待 pancreatic cancer癌症,
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找寻新的、药效更强的治疗胰腺癌的药物
而对于改变治疗病人的手段
03:26
but nothing has been doneDONE
in changing改变 the way
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却没有任何投入
03:29
we deliver交付 them to the patient患者.
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说完两个坏消息
03:32
So after two pieces of bad news新闻,
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我想告诉你们一个好消息,希望是的
03:34
I'm going to give you
good news新闻, hopefully希望.
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03:37
With a collaborator合作者 at MITMIT
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通过麻省理工大学和位于波士顿的
03:39
and the Massachusetts马萨诸塞
General一般 Hospital醫院 in Boston波士顿,
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麻省总医院的合作研究
03:42
we have revolutionized革命性
the way we treat对待 cancer癌症
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我们已经革新了治疗癌症的方式
03:45
by making制造 localized本地化
drug药物 delivery交货 a reality现实.
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使得定位给药成为现实
03:48
We are basically基本上 parachuting跳伞 you
on top最佳 of your destination目的地,
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总的来说就是,我们用降落伞将你在目的地上方直接投送出去
避免你得在高速路上七拐八拐
03:52
avoiding避免 your having to drive驾驶
all around the highway高速公路.
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我们将药物嵌入类似这样的装置中
03:55
We have embedded嵌入式 the drug药物
into devices设备 that look like this one.
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04:01
They are flexible灵活 enough足够
that they can be folded折叠
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它们极为柔软
可以将它们折叠放入导管中
04:06
to fit适合 into the catheter导管,
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医生可以通过微创手术
04:08
so the doctor医生 can implant注入 it
directly on top最佳 of the tumor
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将它直接植入肿瘤上方
04:12
with minimally微创 invasive侵入的 surgery手术.
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04:14
But they are solid固体 enough足够
that once一旦 they are positioned定位的
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同时这种装置又足够坚固
一旦它们被放置到肿瘤上
04:18
on top最佳 of the tumor,
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它们就像一个笼子
04:20
they will act法案 as a cage.
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04:21
They will actually其实
physically物理 prevent避免 the tumor
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通过物理方式阻止肿瘤进入到其它器官
04:25
from entering进入 other organs器官,
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04:26
controlling控制 the metastasis转移.
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从而控制癌细胞扩散
04:30
The devices设备 are also biodegradable可生物降解.
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另外,这种装置是可生物降解的
04:32
That means手段 that once一旦 in the body身体,
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也就是说,一旦进入人体
它们就开始降解
04:34
they start开始 dissolving溶解,
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04:36
delivering交付 the drug药物 only locally本地,
slowly慢慢地 and more effectively有效
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定点地、缓慢地释放药物
相比于目前的全身治疗方式
04:41
than what is doneDONE with the current当前
whole-body全身 treatment治疗.
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这种给药方式更加有效
04:45
In pre-clinical临床前研究 study研究,
we have demonstrated证明
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临床前研究表明
这种定位给药方式
04:48
that this localized本地化 approach途径
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04:50
is able能够 to improve提高 by 12 times
the response响应 to treatment治疗.
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可以提升12倍治疗效果
04:54
So we took a drug药物 that is already已经 known已知
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我们使用某已知药物
将它定点放于最需要的部位
04:57
and by just delivering交付 it locally本地
where it's needed需要 the most,
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05:01
we allow允许 a response响应
that is 12 times more powerful强大,
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使得治疗效果增强了12倍
05:05
reducing减少 the systemic系统的 toxic有毒的 effect影响.
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并且减少了对身体系统的毒副作用
我们正致力于让这项技术更上一层楼
05:09
We are working加工 relentlessly无情 to bring带来
this technology技术 to the next下一个 level水平.
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05:13
We are finalizing敲定 the pre-clinical临床前研究 testing测试
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我们即将完成临床前测试
和向食品药品监督管理局申请临床试验前
05:16
and the animal动物 model模型 required需要
prior to asking the FDAFDA for approval赞同
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规定的动物实验
05:20
for clinical临床 trials试验.
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目前,绝大部分胰腺癌患者都会死于此病
05:22
Currently目前, the majority多数 of patients耐心
will die from pancreatic cancer癌症.
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我们希望,有一天
05:28
We are hoping希望 that one day,
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05:29
we can reduce减少 their pain疼痛,
extend延伸 their life
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我们可以减轻他们的痛苦,延长他们的生命
05:33
and potentially可能 make pancreatic cancer癌症
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使胰腺癌成为一种可治愈的疾病
05:36
a curable固化 disease疾病.
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反思我们的给药方式
05:38
By rethinking重新思考 the way we deliver交付 the drug药物,
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05:41
we don't only make it
more powerful强大 and less toxic有毒的,
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我们不仅使其更有效、更小副作用
我们也为胰腺癌患者和更多其他患者
05:44
we are also opening开盘 the door
to finding发现 new innovative创新 solutions解决方案
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所面临的各种不可能解决的问题
05:49
for almost几乎 all other impossible不可能 problems问题
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打开了找寻革新解决方案的大门
05:52
in pancreatic cancer癌症 patients耐心 and beyond.
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谢谢大家
05:55
Thank you very much.
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05:56
(Applause掌声)
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Translated by jing liu
Reviewed by li lang

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ABOUT THE SPEAKER
Laura Indolfi - Biomedical entrepreneur
Laura Indolfi is revolutionizing cancer treatment with new technologies including implantable devices for delivering drugs locally to the site of a tumor.

Why you should listen

Laura Indolfi is a biomedical entrepreneur, CEO and co-founder of PanTher Therapeutics, an early stage spin-out from MIT and MGH that provides superior technologies for revolutionizing the treatment of locally advanced inoperable solid tumors. Prior to this she served as an entrepreneur-in-residence at the MGH Cancer Center and as a research associate in the Harvard-MIT Institute for Medical Engineering and Science. She was selected as a TED Fellow in 2016.

Indolfi has broad professional experiences and interests ranging from biomedical engineering to entrepreneurship and outreaching initiative to promoting science. Her scientific expertise covers a broad range of therapeutic areas (cardio, cancer, inflammation, regenerative medicine) and approaches (drug delivery, cell therapy, implanted devices). Together with her strong technical background, Laura has hands-on business and managerial know-how developed during her biomedical business training at Sloan and Harvard Business Schools and with several consulting firms. She strongly believes in the power of outreach initiatives to promote research awareness and foster the public audience's discovery of the beauty of science. In 2014 the line of clothes Cytocouture, created in collaboration with Colombian designer Carlos Villamil and inspired by her cell-therapy research, won the global competition Descience.

Indolfi holds a MS/BS degree in materials science and engineering and a PhD in biomaterials from the University of Naples Federico II in Italy. Upon graduation, she joined the Harvard-MIT Division of health, science and technology, working on several projects spanning from devices for local drug delivery to tissue engineering approaches for cell therapies.

More profile about the speaker
Laura Indolfi | Speaker | TED.com