Jakob Magolan: A crash course in organic chemistry
Professor Jakob Magolan is a synthetic chemist who assembles new molecules to discover new medicines. Full bio
Double-click the English transcript below to play the video.
the words "organic chemistry?"
at nearly every university,
introduction to the subject,
that overwhelms students,
to become a doctor or a dentist
perceive this science like this ...
to do to young people,
beyond college campuses long ago.
about these two words.
in which we have placed it
and it's not good for society,
should be easier. It shouldn't.
by the experiences of premed students
a very anxious time of their lives.
of organic chemistry is valuable,
accessible to everybody,
the beat of my heart,
right here will do it.
the ignition switch
go up so blood could rush to my muscles.
I would feel a wave of strength.
between life and death for many people.
that you can hold in your fingers.
when I look at that picture.
together by atomic bonds.
gives epinephrine its identity,
actually seen one of these,
an artistic impression,
how small this is.
half a milligram of it dissolved in water.
molecules in here is one quintillion.
into the right ballpark,
under all the oceans and lakes,
so they fit in here.
we will never see it,
through some sophisticated machines
this molecule very well.
of four different types of atoms,
we typically use for them.
is made of little spheres
of these basic ingredients,
from three smaller particles:
into this familiar table.
doesn't need all of these,
that stand apart from the rest
that are found in epinephrine:
is the most important part.
connect to form molecules,
and you can misspell the word "honk,"
for the rest of your lives.
with these ingredients.
they're made of electrons.
to reach out and hold their neighbors.
like a handshake,
they are not permanent.
and grab another.
and make new molecules.
is made mostly of carbon atoms,
structural building material,
a good number of handshakes
as the study of carbon molecules.
we can think of that follow our rules,
and they have familiar names:
即 H2O、NH3，和 CH4。
H20 and NH3 and CH4.
"oxygen" and "nitrogen" --
that have two atoms each.
and three bonds between them.
and beside it, some flammable fuels.
of just hydrogen and carbon.
We're very creative.
into molecules of oxygen,
or in your barbecues,
一個 CO2 分子的中心，
ends up at the center of a CO2 molecule,
as parts of waters,
for bigger molecules either,
important stories in medical history.
real triumph over physical pain,
and they're read by other scientists,
to do this quickly on paper,
with simple letters,
that lie in the plane of the page,
forwards and backwards,
by corners between the bonds,
that's bonded to a carbon.
any fewer than four bonds.
is the bonds between OH and NH.
和 NH 間的鍵結。
to make it cleaner,
to draw molecules.
but I think everyone here could do it,
They're one and the same.
through your body right now.
a quick quintillion more of them.
of sheep or cattle,
where this stuff comes from.
that come mostly from petroleum.
makes some of us uncomfortable.
which makes us feel safe.
they cannot be distinguished.
that are coming off an assembly line here.
almost mathematical sense.
math practically touches reality.
they don't matter,
this molecule just like we do,
at this than we are.
that are powered by sunlight,
small molecules crash into each other
carbohydrates, proteins, nucleic acids,
with the oxygen gas we breathe,
with the energy of the sun.
to reclaim this word, "chemical,"
and it doesn't mean harmful,
chemical-free lump charcoal.
chemicals are quite toxic,
whether something is harmful
we have these people.
that we call petroleum.
gets converted into a molecule of CO2.
都會被轉換成 CO2 分子。
that is messing up our climate.
will make that reality easier to accept
are not just fossil fuels.
available raw materials
that we call synthesis.
or break them apart with great control.
it's even possible.
into washing machines,
exact copies of nature, like epinephrine,
from scratch, like these two.
of multiple sclerosis;
that we call T-cell lymphoma.
叫做 T 細胞淋巴瘤。
it's like a key in a lock,
with the chemistry of a disease.
to fit snugly somewhere important.
at making them than we are,
two chlorine atoms
in a jungle in Borneo in 1953.
cost-efficiently in a lab.
can harvest it from its natural source,
one of our most powerful antibiotics.
in our literature every day.
in every corner of this planet.
have amazing powers ...
and everything else.
is like being a knight in shining armor.
with courage and composure,
of the blacksmith in this picture,
things would look a little different ...
fabrics, all plastics,
you're sitting on right now --
and they're mostly carbon,
and it goes on and on and on,
you guys organic chemistry --
from a young man named Weston Durland,
student in chemistry,
pretty good with computer graphics.
all the moving molecules
through the use of graphics like these
about this intricate science.
is not something to be afraid of.
of the natural world looks richer.
ABOUT THE SPEAKERJakob Magolan - Organic chemist
Professor Jakob Magolan is a synthetic chemist who assembles new molecules to discover new medicines.
Why you should listen
Jakob Magolan holds the Boris Family Endowed Chair in Drug Discovery at McMaster University in Canada. As a graduate student, he was trained to synthesize the complex and beautiful molecules made by nature from simple chemical building blocks. His medicinal chemistry laboratory now partners with biologists and clinicians to find new molecules and innovative strategies to treat disease. He and his colleagues at McMaster's Institute for Infectious Disease Research are working to discover new antibiotics to combat the threat of drug-resistant microbial infections.
Magolan has taught organic chemistry to hundreds of undergraduate students. He believes in the tremendous value of scientific literacy in society and loves to share his appreciation of science with the public. Magolan prepared this TEDx talk together with graphic designer Weston Durland, who was one of his chemistry students.
Jakob Magolan | Speaker | TED.com