TED2008
Dean Ornish: Your genes are not your fate
Dean Ornish: Geni ne određuju vašu sudbinu
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Dean Ornish govori o novim istraživanjima koja pokazuju kako usvajanje zdravijih životnih navika može utjecati na osobu i kroz promjene na genskoj razini. Ako vodite zdraviji život, zdravo se hranite, puno vježbate i volite, broj vaših moždanih stanica će se povećati.
Dean Ornish - Physician, author
Dean Ornish is a clinical professor at UCSF and founder of the Preventive Medicine Research Institute. He's a leading expert on fighting illness -- particularly heart disease with dietary and lifestyle changes. Full bio
Dean Ornish is a clinical professor at UCSF and founder of the Preventive Medicine Research Institute. He's a leading expert on fighting illness -- particularly heart disease with dietary and lifestyle changes. Full bio
Double-click the English transcript below to play the video.
00:12
One way to change our genes is to make new ones,
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Jedan način da promijenimo svoje gene jest da napravimo nove,
00:14
as Craig Venter has so elegantly shown.
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kao što je to elegantno pokazao Craig Venter.
00:16
Another is to change our lifestyles.
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Drugi način je da promijenimo životni stil.
00:19
And what we're learning is how powerful and dynamic these changes can be,
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Upravo učimo koliko su te promjene snažne i dinamične,
00:23
that you don't have to wait very long to see the benefits.
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i kako ne trebate dugo čekati na rezultate.
00:26
When you eat healthier, manage stress, exercise and love more,
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Kada zdravije jedete, kontrolirate stres, vježbate i volite više,
00:31
your brain actually gets more blood flow and more oxygen.
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vaš mozak dobiva više krvi i kisika.
00:33
But more than that, your brain gets measurably bigger.
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Još važnije jest da vaš mozak tada ustvari raste.
00:36
Things that were thought impossible just a few years ago
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Stvari koje su prije par godina smatrane nemogućim
00:38
can actually be measured now.
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danas se mogu izmjeriti.
00:40
This was figured out by Robin Williams
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To je shvatio Robin Williams
00:43
a few years before the rest of us.
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par godina prije nas ostalih.
00:45
Now, there's some things that you can do
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Ovo su stvari koje možete napraviti
00:47
to make your brain grow new brain cells.
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kako bi vaš mozak proizvodio nove moždane stanice.
00:50
Some of my favorite things, like chocolate and tea, blueberries,
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Neke od meni najdražih su čokolada i čaj, borovnice,
00:52
alcohol in moderation, stress management
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alkohol u umjerenim količinama, kontroliranje stresa
00:56
and cannabinoids found in marijuana.
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i opioidi koji se mogu naći u marihuani.
00:58
I'm just the messenger.
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Ja sam samo glasnik.
01:01
(Laughter)
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(Smijeh)
01:04
What were we just talking about?
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O čemu smo ono upravo pričali?
01:07
(Laughter)
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(Smijeh)
01:09
And other things that can make it worse,
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A ove stvari mogu sve pogoršati
01:11
that can cause you to lose brain cells.
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i uzrokovati gubitak moždanih stanica.
01:13
The usual suspects, like saturated fat and sugar,
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Uobičajeni krivci, poput zasićenih masti i šećera,
01:16
nicotine, opiates, cocaine, too much alcohol and chronic stress.
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nikotina, opijata, kokaina, previše alkohola i kroničnog stresa.
01:20
Your skin gets more blood flow when you change your lifestyle,
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Vaša koža je bolje prokrvljena kada promijenite životni stil
01:23
so you age less quickly. Your skin doesn't wrinkle as much.
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i zato sporije starite i imate manje bora.
01:26
Your heart gets more blood flow.
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Kroz vaše srce prolazi više krvi.
01:28
We've shown that you can actually reverse heart disease.
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Dokazali smo da možete izliječiti srčane bolesti.
01:30
That these clogged arteries that you see on the upper left,
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Ove začepljene arterije gore lijevo
01:33
after only a year become measurably less clogged.
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su nakon samo jedne godine mnogo manje začepljene.
01:35
And the cardiac PET scan shown on the lower left,
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Na PET scan-u dolje lijevo
01:37
the blue means no blood flow.
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plava boja označava slab protok krvi.
01:39
A year later -- orange and white is maximum blood flow.
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Nakon godinu dana narančasta i bijela boja pokazuju snažan protok.
01:42
We've shown you may be able to stop and reverse the progression
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Vi ste u mogućnosti zaustaviti i poništiti tijek
01:45
of early prostate cancer and, by extension, breast cancer,
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ranog raka prostate, kao i raka dojke
01:47
simply by making these changes.
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ako unesete ove promjene u svoj život.
01:49
We've found that tumor growth in vitro was inhibited
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Rast tumora in vitro zaustavljen je
01:52
70 percent in the group that made these changes,
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u 70 posto ispitanika koji su promijenili svoje navike,
01:54
whereas only nine percent in the comparison group.
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i u samo devet posto onih koji to nisu učinili.
01:57
These differences were highly significant.
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Ove su razlike veoma značajne.
01:59
Even your sexual organs get more blood flow,
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Čak i vaši spolni organi dobivaju više krvi
02:01
so you increase sexual potency.
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čime se povećava vaša spolna moć.
02:03
One of the most effective anti-smoking ads was done
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Najučinkovitiju reklamu protiv pušenja
02:05
by the Department of Health Services,
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napravilo je ministarstvo zdravstva koje je
02:07
showing that nicotine, which constricts your arteries,
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pokazalo da nikotin sužava vaše arterije
02:09
can cause a heart attack or a stroke,
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i može uzrokovati srčani i moždani udar,
02:11
but it also causes impotence.
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ali isto može dovesti i do impotencije.
02:13
Half of guys who smoke are impotent.
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Polovica muškaraca pušača pati od impotencije.
02:15
How sexy is that?
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Seksi, zar ne?
02:16
Now we're also about to publish a study --
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Uskoro ćemo objaviti istraživanje koje pokazuje
02:18
the first study showing you can change gene expression in men with prostate cancer.
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da je moguća promjena gena u oboljelih od raka prostate.
02:21
This is what's called a heat map --
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Ovo je toplinska karta,
02:23
and the different colors -- and along the side, on the right, are different genes.
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s različitim bojama. Geni su s desne strane.
02:26
And we found that over 500 genes were favorably changed --
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500 gena se promijenilo nabolje
02:29
in effect, turning on the good genes, the disease-preventing genes,
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i aktiviralo "dobre" gene koji sprječavaju bolesti
02:32
turning off the disease-promoting genes.
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te poništilo one gene koji uzrokuju bolesti.
02:36
And so these findings I think are really very powerful,
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Ove spoznaje su veoma snažne jer
02:39
giving many people new hope and new choices.
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mnogim ljudima pružaju novu nadu i izbor.
02:41
And companies like Navigenics and DNA Direct and 23andMe,
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Tvrtke kao Navigenix, DNA Direct i 23andME koje
02:46
that are giving you your genetic profiles,
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izrađuju vaše genske profile
02:49
are giving some people a sense of, "Gosh, well, what can I do about it?"
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kod ljudi izazivaju pitanje: "Što ja sad tu mogu napraviti?"
02:52
Well, our genes are not our fate, and if we make these changes --
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Naši geni ne određuju našu sudbinu. Oni jesu
02:55
they're a predisposition -- but if we make bigger changes
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predispozicija za bolesti, ali ako napravimo promjene
02:57
than we might have made otherwise,
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koje inače ne bismo,
02:59
we can actually change how our genes are expressed.
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možemo promijeniti način na koji naši geni rade.
03:02
Thank you.
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Hvala vam.
03:03
(Applause)
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(Pljesak)
ABOUT THE SPEAKER
Dean Ornish - Physician, authorDean Ornish is a clinical professor at UCSF and founder of the Preventive Medicine Research Institute. He's a leading expert on fighting illness -- particularly heart disease with dietary and lifestyle changes.
Why you should listen
Dr. Dean Ornish wants you to live longer, and have more fun while you're at it. He's one of the leading voices in the medical community promoting a balanced, holistic approach to health, and proving that it works. The author of Eat More, Weigh Less and several other best-selling books, Ornish is best known for his lifestyle-based approach to fighting heart disease.
His research at the Preventive Medicine Research Institute (the nonprofit he founded) clinically demonstrated that cardiovascular illnesses -- and, most recently prostate cancer -- can be treated and even reversed through diet and exercise. These findings (once thought to be physiologically implausible) have been widely chronicled in the US media, including Newsweek, for which Ornish writes a column. The fifty-something physician, who's received many honors and awards, was chosen by LIFE Magazine as one of the most influential members of his generation. Among his many pursuits, Ornish is now working with food corporations to help stop America's obesity pandemic from spreading around the globe.
Dean Ornish | Speaker | TED.com