Faith Osier: The key to a better malaria vaccine
费思·奥斯勒: 提高疟疾疫苗的关键
Faith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines. Full bio
Double-click the English transcript below to play the video.
in Africa every year,
about malaria vaccines.
are simply not good enough.
做的不够好的地方。
for 100 plus years.
of what the parasite really looked like.
the parasite really is.
has remained pretty rudimentary.
we must go back to basics
我们必须回到根本
handle this complexity.
如何处理这种复杂性。
infected with malaria
but they don't get ill.
但他们没有生病。
who had overcome malaria
样本进行了研究
antibody response look like?"
on the radar for malaria vaccines.
疟疾疫苗没什么关系。
important parts of the parasite.
寄生虫的重要部分。
a protein of interest,
一种有趣的蛋白质时，
important for a vaccine
participants in a village in Africa,
的三百个参与者，
would predict who got malaria
预测谁得了疟疾，
a small number of proteins
30 years of this type of research
我的团队花费了30年，
conducted over just three months.
完成的一个激动人心的实验。
in seven African countries,
and the variable intensity
to prioritize our parasite proteins,
我们使用组学智能
the malaria parasite on a chip.
重新创造了疟原虫。
and we're very proud of that.
并为此感到非常自豪。
on over 100 antibody responses.
超过100个抗体反应。
antibody response,
what might make a good malaria vaccine.
怎样才能研制出好的疟疾疫苗。
do to the parasite.
杀死它们（寄生虫）的？
Is there synergy?
有协同作用吗?
a bit of one antibody won't be enough.
一个抗体是不够的。
concentrations of antibodies
kill the parasite in multiple ways,
以多种方式杀死寄生虫，
may not adequately reflect reality.
可能不能充分反映现实。
in greater definition,
看到的寄生虫一样
overcome this complexity.
这个问题的复杂性。
the breakthroughs that we need
我们需要的突破，
through vaccination.
使疟疾成为历史。
are we actually to a malaria vaccine?
发展到什么程度了?
at the beginning of a process
what we need to put in the vaccine
but we're getting there.
但我们正在努力。
tell me what does it stand for
告诉我它代表什么
Malaria Antigen Research Partnership.
疟疾抗原研究合作企业。
is referring to us in Africa,
in collaboration,
and looking to Europe,
some strength within Africa.
一股强大的力量。
to develop a malaria vaccine,
of disease in Africa is high,
to push the boundaries
mentioned this a little bit,
你提过一点，
if there were a malaria vaccine?
会有怎样的变化呢?
half a million lives every year.
拯救50万条生命。
12 billion US dollars a year.
每年120亿美元的代价。
ABOUT THE SPEAKER
Faith Osier - Infectious disease doctorFaith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines.
Why you should listen
Faith Osier works to understand how humans acquire immunity to malaria and intends to use this knowledge to design highly effective vaccines. Her studies focus on infections with the parasite Plasmodium falciparum, which leads to nearly half a million deaths in Africa each year. She demonstrated that Kenyan children who did not get sick after a malaria infection had high levels of antibodies against combinations of specific proteins found within the parasite. Subsequently, her studies in immune African adults revealed that there were in fact many additional parasite proteins that could be considered for malaria vaccines. To verify her results, she designed a massive study involving children and adults from 15 different geographical locations in Africa. She designed KILchip, a custom protein microarray that enabled her team to analyze antibody responses to more than 100 intentionally selected malaria proteins in these human blood samples. Her research group also studies the mechanisms by which these antibodies kill malaria parasites.
Osier is a Professor of Malaria Immunology in the Nuffield Deptartment of Medicine at the University of Oxford, UK. She has two research laboratories: one in the Biosciences Deptartment of the KEMRI-Wellcome Trust Research Programme in Kilifi, Kenya, and the other in the Parasitology Deptartment of Heidelberg University Hospital in Heidelberg, Germany. She has won multiple awards for her work including the Royal Society Pfizer Award (UK) and the prestigious Sofja Kovalevskaja Award from the Alexander von Humboldt Foundation. She holds major research grants from the Wellcome Trust, is an MRC African Research Leader and an EDCTP Senior Fellow. She is also a fellow of the African Academy of Sciences, an advisor to the Executive Committee of the Federation of African Immunological Societies and the vice-president/president-elect of the International Union of Immunological Societies. She was named a TED Fellow in 2018. She is passionate about training African scientists to excel and deliver the medical interventions that are urgently needed on the continent.
Faith Osier | Speaker | TED.com